We travel to the Czech capital for the first of two legs on September 14 with the return of European football at the Lane a fortnight later on September 28.
Boss Martin and assistant Chris travelled to Prague last weekend to watch Slavia comfortably beat bottom side Sigma Olomouc 3-0 and make it three wins and two defeats in their opening five league games.
Martin reported: "Czech football is at a high level and the national team is probably as good as the England team. It will be tough but Im positive.
"They play in a 4-4-2, they have good strikers, one is on the fringe of the national team and the other scored a couple of goals and is a very good header of the ball.
"They have a good left winger, the captain in midfield is experienced and at the back Martin Latka who was at Birmingham last season, he looked comfortable on the ball. In short, they have a decent side who play for each other."
Chris added: "They looked reasonably comfortable. They had quality across midfield and in offensive areas and didnt move too much away from that 4-4-2 system.
"They are all accomplished players on the ball and you get the feeling that they are a side good enough to raise their game on the big occasions. They also have experience of playing in European competition on a regular basis. We will look at them again before we play them and it wont be an easy game, thats for sure."
Martin Jol and Chris Hughton run the rule over our UEFA Cup first round opponents Slavia Prague.