The central defender has been struggling with the problem for a number of weeks and has dropped out of contention for the Villa Park encounter.
"Ledley has been suffering with a groin problem for a while," reported Dr Charlotte Cowie this afternoon. "We have tried to keep him going but it has gradually become more and more uncomfortable. "He has played many matches this season and it gets to a point where he can't just keep going and needs a bit of a break."
Dr Charlotte's Treatment Table feature will appear here on the site tomorrow morning.
Ledley King has been withdrawn from the England squad to face Holland on Wednesday due to a groin injury.