Dominique joins Martin Jol, Chris Hughton and Hans Segers as an important part of Santini's back-up team.
He spent last season with FC Grenoble after three successful seasons with Olympique Lyonnais as assistant to Santini. Together they steered the club to two French championships and success in the French League Cup.
Prior to Lyonnais he spent 15 years coaching Auxerre where he had played for 10 years, having started his professional career with Metz.
"I am delighted that Dominique has agreed to join us and know that he will be a success here," said Jacques. "He is the complete coach in that he covers all areas from rehabilitation through to specialist training and provides tremendous support and expertise."
Jacques Santini has today completed his new-look Spurs coaching team with the appointment of highly rated French coach Dominique Cuperly.