The young midfielder, 19, earning his fourth senior cap, initially won the ball in midfield before unleashing a spectacular 25-yard drive beyond Spurs team-mate and France captain Hugo Lloris into the top corner in the 39th minute.
Dele then set-up England's second goal, again winning the ball in midfield before releasing Raheem Sterling, who crossed for Wayne Rooney to volley home two minutes into the second half.
Eric Dier also earned his first start for the Three Lions on a poignant evening at Wembley after Friday's atrocities in Paris.
We had four players on the pitch at start of play - Hugo, Dele, Eric and Harry Kane. Harry played for 80 minutes, Dele for 88 while Hugo and Eric completed the full game. Ryan Mason and Kyle Walker were unused substitutes.
Harry went close on a few occasions, testing Hugo down to his left in the first half before fizzing a shot just wide in the second half.
Dele was voted Man of the Match and went off to a standing ovation.