We were drawn against Kevin Keegan's men for a place in the quarter-finals after last night's victory against West Ham in round three.
Caretaker boss David said: "It's a tough draw but we're at home and we've got to make that count.
"We've got to play with tempo - the philosophy at home and away tends to be slightly different, we tend to have more possession at home than away so it's a different way of playing.
"Manchester City had a very strong second half against us in the goalless at Manchester, where we survived and Kasey Keller played very well.
"I think it will be a good game for us. It's certainly set up for that - it's a one-off and that adds to the excitement on the night."
David Pleat says it's vital we make home advantage count when we face Manchester City in the next round of the Carling Cup.