The strikers accounted for four of the five goals as England kicked-off their European Championship qualfying campaign with a 5-0 hammering of Andorra at Old Trafford on Saturday.
With Michael Owen still injured and Wayne Rooney suspended, boss Steve McClaren is expected to go again with the same strike partnership in Skopje, kick-off 8pm.
The Liverpool hitman and former Spurs forward can see no reason why the pair cannot fire England to another win in their second Group E outing.
"I really enjoy playing with Jermain," said Crouch. "I did it at Under-18 and Under-21 level for England, so it is good to have the opportunity to work with him at senior level too.
"We all know he is a top-class player and if he gets the chances, he will take them.
"I know his game, he knows mine and overall, we complement each other really well."
Peter Crouch has sung the praises of Jermain Defoe as the pair look set to spearhead England's attack again in Macedonia on Wednesday night.