Capped 92 times by the US, Clint has scored 31 international goals including six in the current qualifying campaign for the 2014 World Cup.
That campaign in the North/Central America and Caribbean qualfying zone is now at its final stage, with six teams - USA, Mexico, Costa Rica, Honduras, Panama and Jamaica - vying for three automatic places for Brazil. The fourth-placed team goes into a play-off.
The USA are looking to bounce back from a defeat against Honduras in the first of their 10 qualifying matches.
Legendary former Spurs striker and current USA coach Jurgen Klinsmann announced the captaincy on Wednesday.
"Clint is one of our most experienced players and ready to assume a more vocal leadership role,” he told ussoccer.com. “He has been huge for us in World Cup Qualifying so far and is already one of our key leaders. We know he will do a great job for these two important games."
Clint, named US Soccer Male Athlete of the Year for the third time at the end of last year, has worn the armband once before against Colombia in October, 2010.
The US take on Costa Rica in Denver on Friday before a huge match against Mexico in Mexico City on Tuesday.