Having coped with the battering ram style of Mark Viduka and aggression of Alan Smith against Leeds at the Lane on Saturday he faces the pace, guile and constant threat of Liverpool's England star Michael Owen on Wednesday night.
"It's a totally different game," considered Anthony. "He's a sharper player looking to run in behind and it's different from what you get from Smith and Viduka, which is a lot more physical.
"He can turn very quickly and you know he's going to look to run in behind you a lot, so you can prepare to a certain extent for that."
Tony and the rest of the defence will need little reminding of the explosive nature of Owen's game - having kept him quiet for the most part at Anfield last season, Owen's burst into the box ended up with him winning a penalty that he converted for the winner four minutes from time.
Indeed, Gardner is in little doubt that Owen at Anfield represents one of the toughest challenges on the Premiership calendar.
"Michael's up there with the best of them," he added. "His record speaks for itself and he's only still young really.
"His goalscoring record is already phenomenal for someone his age. We know we'll have to be on our game throughout the 90 minutes to keep him at bay.
"We've played well there last couple of seasons, worked hard and it's not gone our way. Hopefully if we can play well again, it will go our way this time."
For the record, Owen, still just 23, has netted 103 goals in 166 Premiership starts for Liverpool and will surely crack England's all-time scoring record - he has 22 goals in 50 caps as he aims for Bobby Charlton's mark of 49 in 106.
The threat facing Anthony Gardner and his defensive colleagues goes from one extreme to another at Anfield.