Southend caused the shock of the 4th round by defeating Manchester United at Roots Hall through a Freddy Eastwood free-kick.
The ties will be played in the week commencing December 18.
Tottenham Hotspur v Southend United
Liverpool v Arsenal
Newcastle United v Chelsea
Charlton Athletic v Wycombe Wanderers
We have been drawn at home to Southend United in the quarter-finals of the Carling Cup.