Our French international goalkeeper was stretchered off with a leg injury in the opening stages of our last Premier League outing against Leicester City a fortnight ago.
And Head Coach Mauricio Pochettino has confirmed the 28-year-old will not be fit to face the Clarets at Turf Moor.
Striker Roberto Soldado is also a doubt, having missed our last two matches with a knee problem.
“Hugo Lloris is still recovering after his problem against Leicester – he is out,” confirmed Mauricio.
“After that, Roberto Soldado is a doubt but we have two days ahead to decide if it’s possible for him to make the squad.”