Martin Jol made three changes from the draw at Villa - Ledley King back from injury in place of Calum Davenport, Tom Huddlestone in for Didier Zokora while Robbie Keane partnered Dimitar Berbatov up from with Jermain Defoe on the bench.
THE KEY ACTION...
8mins: Electric atmosphere but a quiet start on the pitch, nothing in terms of goalmouth action yet, we've enjoyed decent spells of possession.
11mins: GOAL DISALLOWED. Good move ended with Ghaly squaring to Murphy, he drove low from 25 yards, Runje parried diving low to his left and Berbatov tapped home the rebound - from an offside position.
16mins: Another passing sequence ended with Zan having to head Ghaly's cross away for a corner with Murphy closing in. From the corner, Berbatov looped header into Runje's hands.
19mins: YELLOW CARD - SPURS. Chimbonda for dissent.
25mins: Jenas' corner headed out to Assou-Ekotto, who lashed shot over from 30 yards.
30mins: First real opening for the home side, Toroman got to the byline, right side, cutback to Sedef who was closed down quickly by Ghaly and shot wide.
31mins: GOAL - SPURS. Berbatov controlled Robinson's long clearance and fed in Ghaly, bursting into box from the right, suddenly through one-one-one, Runje initially saved with his legs but the ball cannoned back off Ghaly's knee and home.
Besiktas 0, Spurs 1
35mins: Nobre flung himself in for diving header that zipped just wide from 12 yards.
36mins: DOUBLE SAVE. Burak Yilmaz fierce free-kick from 30 yards initally parried up into the air by Robinson, he got back up to his feet and pushed the falling ball out from under the crossbar under severe pressure from Nobre.
43mins: Assou-Ekotto played ball down the line for Berbatov to chase, he got better of physical battle with Toroman and played clever pass to Murphy, tight angle, drilled effort wide.
44mins: Fraction of hesitation in defence allowed Nobre site of goal, tight angle, fired high and wide.
Half-time: Besiktas 0, Spurs 1
Half-time: SUB - BESIKTAS. Da Silva for Sedef.
51mins: YELLOW CARD - BESIKTAS. Toroman for foul on Berbatov.
51mins: Half-chance as Jenas got in front of his marker to meet Murphy's free-kick but could only loop header skywards.
52mins: Berbatov control and volley from right corner of box forced save out of Runje.
57mins: YELLOW CARD - SPURS. Ghaly for kicking ball away.
58mins: Uzulmez squared from left touchline for Kurtulus to pull the trigger from 30 yards, decent hit that deflected just wide off King.
63mins: GOAL - SPURS. Berbatov controlled King's pass, turned Mercimek, side-stepped Runje and slotted home.
Besiktas 0, Spurs 2
65mins: SUB - BESIKTAS. Akin for Tatan.
66mins: WOODWORK. Berbatov beat Mercimek in right channel and picked out Keane whose volley into the ground beat Runje only to come back off the crossbar.
67mins: CHANCE. Keane again, this time left channel of box, drilled left-foot shot wide.
70mins: Borak Yilmaz dragged shot well wide from 30 yards.
71mins: CHANCE. Fantastic one-touch passing move involving Huddlestone, Berbatov and Ghaly led to Ghaly feeding in Keane, left side of box, went for side-foot but could only shoot straight at Runje.
72mins: PENALTY? Berbatov had beating of Mercimek again, into box, went over under clumsy challenge but referee waved appeals away.
79mins: SUB - SPURS. Ziegler for Murphy.
82mins: SUB - SPURS. Lennon for Ghaly.
86mins: SAVE. Burak Yilmaz - home side's best player on night - controlled, turned and half-volleyed effort from 18 yards that Robinson claimed well diving to his right.
89mins: SUB - SPURS. Defoe for Berbatov.
Full time: Besiktas 0, Spurs 2
Besiktas: Runje, Kurtulus, Sedef (Da Silva, 46), Zan, Borak Yilmaz, Mercimek, Nobre, Rodriguez, Uzulmez, Tatan (Akin, 65), Toroman. Subs: Sahin, Dogan, Gulec, Tandogan, Gunes.
Spurs: Robinson, Chimbonda, Dawson, King, Assou-Ekotto, Ghaly (Lennon, 82), Huddlestone, Jenas, Murphy (Ziegler, 79), Berbatov (Defoe, 89), Keane. Subs: Cerny, Davids, Stalteri, Gardner.
Referee: Nicolai Vollquartz. Assistants: Bill Rene Hansen, Bo Abildgaard. Fourth official: Peter Rasmussen.
All the action from Thursday night's excellent UEFA Cup group stage win in Istanbul.