Harry Redknapp insists the lads have to forget Wednesday's Champions League glory and get straight back to the business of winning Premier League points.
Wigan are the visitors to White Hart Lane for a 3pm kick-off on Saturday.
The Latics have suffered a disappointing start to the campaign with 4-0 and 6-0 home losses to Blackpool and Chelsea respectively.
They won't need reminding either of the corresponding fixture here last season - Jermain Defoe scored five goals in a 9-1 victory.
However, Harry believes that poor start will inspire Roberto Martinez's men, who will return to N17 with a big point to prove.
"They've had a couple of setbacks and I'm expecting a tough game, really tough," said Harry.
"I've got a lot of respect for the manager there, a young guy with a great future and I think he'll have them ready to play, that's for sure.
"They did very well for half-an-hour against Chelsea last week, you couldn't see them getting beaten but then suddenly it all turned around, and Chelsea can do that to anyone.
"They will be strong and difficult to beat."
The glory, glory nights returned to the Lane on Wednesday with a 4-0 win against Young Boys taking us through to the group stages of the Champions League.
Since then, Champions League hype has hit fever pitch with us drawn against reigning champions Inter Milan, Werder Bremen and FC Twente in Group A.
"We will have to lift ourselves after the euphoria of Wednesday night," added Harry.
"We're back to league business now and that's all important for us.
"We've been down this road before with a game that people expect us to win and they prove to be the toughest games.
"It's a challenge for me and for the players. The good teams play in the Champions League and then play well in the league. If you want to be up there you have to do that."
SPURS HOLIDAY CLUB
The Wigan match is brought to you by the Spurs Holiday Club.
Thomas Cook Sport, Official Travel Partner of Tottenham Hotspur offer discounted holidays to fans through the Spurs Holiday Club. Fans are able to purchase holidays at guaranteed reduced prices from any Thomas Cook or Going Places store.
For more information, pop into your local store or visit: www.thomascooksport.com