Roberto Soldado completed his hat-trick from the penalty spot in the second half after scoring twice before the interval, with Ewerton having notched for the visitors shortly before the break.
Lewis Holtby added his name to the scoresheet before Roberto's spot kick success.
Spurs: Friedel, Naughton, Capoue, Fryers, Rose (Fredericks 45), Dembele (Eriksen 64), Holtby, Lamela, Sigurdsson, Townsend, Soldado (Coulthirst 77). Substitutes (not used): Archer, Dawson, Chadli, Dombaxe.
Anji: Pomazan, Agalarov (Angbwa 80), Ewerton, Epureanu, Grigalava, Burmistrov, Jucilei, Maksimov, Sobolev, Razak (Gatagov 85), Serderov. Substitutes (not used): Dzhenetov, Tagirbekov, Adeleye.
Goals: Spurs – Soldado 7, 16, 69 pen, Holtby 54; Anji – Ewerton 42.
Yellows: Spurs – Holtby, Naughton; Anji - Maksimov.
Referee: Kennet Stefan Johannesson (Sweden).