United sit second in the Premier League after a typically impressive start to the campaign and four wins in five.
We head to Manchester for a 5.30pm kick-off having stretched our unbeaten run to six matches in all competitions, moving up to eighth after back-to-back wins over Reading and QPR.
“It’s a difficult game, of course,” said Andre. “It would be tremendous for us to go there and win, because we would really move up the table, join the top group and that would have an important meaning for everyone at this time.
“Obviously, we know the task, to go to United and win is always extremely difficult.
“But as long as there is belief, as long as there is motivation, there is certainly more chance of getting it.”
It was suggested that the belief was there. “I think so,” added Andre. “In the end, we’ve been doing well, the team has been evolving in terms of performance and we’ve put in the effort on a tight schedule at the moment.
“We’re playing games and only having two days’ recovery, but really the belief is there and the confidence is there. We want to take that to United to see if we can get something positive.”
Andre was delighted with Wednesday night's 3-0 win at Carlisle in the Capital One Cup.
"We made some changes and the way we performed was absolutely outstanding," he said.
"To see players like Michael Dawson and Tom Huddlestone feeling so good on the pitch and performing at that level was extremely important for us.
"Also, the younger boys in the team really put on a performance. Ryan Mason, outstanding, Adam Smith, Yago Falque too, good signs for us.
"Overall, let’s not look at individuals, everyone was excellent. When you go to games like that you have to be up for it in terms of motivation, and the boys really showed that."
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If so, here is where Saturday's match at Old Trafford will be televised worldwide - all times in the table below are local time - we kick-off at 5.30pm UK.