The Italian giants travel to the Lane for Matchday One of six in Group J, kicking-off at 8.05pm.
Lazio have made a 100-per-cent winning start in Serie A after three games and travel to London on the back of a 3-1 win at Chievo on Sunday.
Delighted with the result and performance to secure a first victory of the campaign at Reading on Sunday, Andre is looking to take that form into a competition he knows all about - he won it with FC Porto in 2010.
"This competition is very important," said Andre, who insisted he will be fielding a 'strong team'.
"It's a tough competition, you have to play 15 games before you reach the final, so it's hard and strenuous and the best teams out of the Champions League are playing.
"It gives access to the European Super Cup and, for me, I always thought it was a prestigious competition and it should be promoted like that because after the Cup Winners’ Cup disappeared, it is not only about the Champions League.
"If we can win a trophy, that represents a lot for Tottenham Hotspur's history as well and would be something really special."
We'll also face Panathinaikos of Greece and Maribor of Slovenia in Group J.
Tickets for Thursday night's match - priced at Category C - are now available for One Hotspur Bronze and Lilywhite Members.
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